Abiotic factors governs the most deleterious factor thereby having antagonistic effect on plant growth and development, resulting in drastic reduction in productivity of horticultural as well as agronomical crops. Abiotic stresses, such as drought, salinity, extreme temperatures, chemical toxicity and oxidative stress are serious threats to horticulture and result in the deterioration of the environment. Abiotic stress causes a wide range of edapho-morphological and physio-chemical changes that dversely affect the development as well as the productivity of fruit crops. Abiotic stress negatively affects the growth and development and plant response to these stresses have tremendous sit fall in the bio-molecular mechanism of horticultural crops. Bio-regulators such as auxins, brassinosteroids, polyamines, and jasmonic acid are chemical substances that have been used in horticulture with increasing incidence to modify the growth and development of plants. The stress conditions alter PGRs levels which help in plant adaptation through their responses on activities of anti-oxidant enzymes, stomatal functioning, plant water balance, nutrient allocations, and source-sink transitions. Bio-regulators are potent and action specific in alleviating the adverse effects of abiotic stress in plants. Application of Bio-regulators has been shown to be beneficial for plants in stress environments. PGRs can regulate various plant metabolic processes, modulate the production of varied osmolytes and secondary metabolites, and these help in maintaining plant-nutrients status in better condition. Hence to protect plants under abiotic stress conditions, bio-regulators command use.