The present experiment on ‘Effect of inorganic fertilizer dose and vermicompost on growth and yield of guava (Psidium guajava L.) cv. Allahabad Safeda’ was conducted on two years old guava at Research Field, College of Agriculture, Teerthanker Mahaveer University Moradabad. The experiment was laid out in Randomized Block Design (R.B.D) with 4 replications and 11 treatments. The treatments included different levels of inorganic fertilizer and vermicompost. The maximum increase in plant height (155.71 cm), number of branches (25.23),and canopy spread E-W direction (101.88 cm) and N-S direction (104.88 cm), was obtained with the application of T₁₀ [50% RDN through chemical fertilizer +50% RDN through vermicompost (100:50:50 g NPK + 1kg vermicompost. Maximum number of flowers/plant (18.25), fruit set (48.42%), fruit length (7.57 cm), fruit diameter (7.78 cm), volume of fruit (118cm³) and specific gravity (1.14 g/ml), were recorded with the application of T₁₀ (50% RDN through chemical fertilizer +50% RDN through vermicompost) which was superior as compared to other treatments taken under present study.The maximum average fruit weight (128g) and number of fruits per tree (8.53) as well as significant highest yield per tree (959.14g) were obtained with the application of 50% RDN through chemical fertilizer +50% RDN through vermicompost (T₁₀). The maximum total soluble solids(12.04⁰Brix), ascorbic acid (180.89mg/100g pulp) and minimum titratable acidity (0.51%) were recorded with the soil placement of 50% RDN through chemical fertilizer +50% RDN through vermicompost (T₁₀) which was superior and economically viable as compare to other treatments with a maximum cost benefit (C:B) ratio of 1: 1.04.